004 — SL-2026-004

GLP-1

Glucagon-Like Peptide 1

GLP-1 is the natural hormone behind the Ozempic and Wegovy effect — and this is the research peptide form of the original molecule. Controls appetite, stabilizes blood sugar, slows digestion. Study the exact mechanism driving the world's most talked-about weight-loss class.

✓ In Stock Lyophilized Powder 5 mg / vial COA Included
€39.90 €54.90
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SKUSL-GLP1-5
FormLyophilized Powder
Quantity5 mg / vial
Purity≥98% HPLC
CAS Number89750-14-1
Molecular FormulaC149H246N44O45
Molecular Weight3297.68 g/mol
Storage−20°C, protect from moisture
Shelf Life24 months (unopened)
ReconstitutionSlightly acidic water pH 4–5 or PBS, 0.5 mg/mL typical
Overview

What is GLP-1?

GLP-1 (Glucagon-Like Peptide 1) is the natural hormone your body produces after eating — it tells your pancreas to release insulin, tells your brain you're full, and slows down digestion. It's produced in your gut within minutes of a meal and acts across multiple organs: pancreas, brain, heart, kidneys, and gut.

It's also the foundational molecule for the most talked-about drug class in medicine right now. Ozempic, Wegovy, Mounjaro — all of these are engineered analogues designed to mimic and extend the effects of natural GLP-1. Studying native GLP-1 directly gives unmediated access to the exact mechanisms these drugs are built on — without prescriptions, without pharmaceutical markups, and without the confounding effects introduced by long-acting modifications.

Native GLP-1 has a very short half-life (~2 minutes) — which makes it ideal for precise, controlled research. You can study the on/off receptor dynamics, the glucose-dependent insulin response, the appetite pathway — with complete temporal control. Sharp Labs GLP-1 is supplied as lyophilized powder at ≥98% HPLC purity, with Certificate of Analysis included with every order.

Key Benefits

What it's
known for.

Appetite Control
Acts on GLP-1 receptors in the hypothalamus and brainstem to powerfully signal fullness and reduce food intake. The central satiety mechanism is the core driver behind GLP-1-based weight loss drugs — studying it with native GLP-1 enables clean, unconfounded dissection of the appetite pathway.
Blood Sugar Regulation
Stimulates insulin secretion only when blood glucose is elevated — an intrinsic safety mechanism that prevents hypoglycaemia. Simultaneously suppresses glucagon from alpha-cells. This glucose-dependent mechanism is what makes GLP-1 receptor agonists safer than older diabetes medications.
Weight Management
Slows gastric emptying, reduces caloric intake via central satiety, and promotes beta-cell survival for long-term metabolic health. These three combined mechanisms are exactly what drives the remarkable weight loss seen in Ozempic and Wegovy trials — and native GLP-1 is the molecule at the root of all of it.
Cardiovascular Health
GLP-1 receptors are expressed in cardiomyocytes and vascular endothelium. Research documents improved endothelial function, reduced ischemia-reperfusion injury, and anti-inflammatory effects in cardiac models. Cardioprotective effects of GLP-1 drugs in large clinical trials have since confirmed these preclinical signals.
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