003 — SL-2026-003

Semax

ACTH(4-7) Pro-Gly-Pro

Semax is the cognitive performance peptide — originally developed in Russia for stroke recovery, now one of the most popular nootropic peptides in Europe. It rapidly elevates BDNF, the brain growth factor behind learning, memory, and mental sharpness.

● Low Stock Lyophilized Powder 30 mg / vial COA Included
€37.90
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SKUSL-SEMAX-30
FormLyophilized Powder
Quantity30 mg / vial
Purity≥98% HPLC
CAS Number80714-61-0
Molecular FormulaC37H51N9O10S
Molecular Weight813.92 g/mol
Storage−20°C, protect from light
Shelf Life24 months (unopened)
ReconstitutionSterile or bacteriostatic water, 1 mg/mL typical
Overview

What is Semax?

Semax is a synthetic peptide originally developed by scientists at the Institute of Molecular Genetics in Moscow. It was designed for stroke recovery — and it has clinical approval in Russia for exactly that. But it's become far more widely known as one of the most effective nootropic peptides available, with a fast-acting, well-documented profile that's attracted serious interest from the biohacking and cognitive performance community.

Its primary and most reproducible effect is rapid elevation of BDNF — brain-derived neurotrophic factor, the key molecule driving neuroplasticity, long-term potentiation, and neuronal survival. BDNF elevation is detectable in hippocampal and cortical tissue within hours of administration. Beyond BDNF, Semax modulates dopaminergic and serotonergic systems — translating into improved mood, motivation, and mental energy in research models.

Unlike many cognitive compounds, Semax has no interaction with the hormonal (cortisol/adrenal) axis — making it a clean tool for studying CNS effects in isolation. Sharp Labs Semax is supplied as a lyophilized powder at ≥98% HPLC purity, with a Certificate of Analysis included with every order.

Key Benefits

What it's
known for.

Memory & Mental Focus
Rapidly elevates BDNF in hippocampal and cortical tissue — the key neurotrophin behind learning, memory retention, and cognitive clarity. Elevation detectable within hours, persisting 24–48h at higher doses. The most consistently reproduced finding in Semax research across multiple labs and models.
Mood & Motivation
Modulates dopamine receptor density in the striatum and serotonergic transmission in cortical regions — translating into improved drive, mental energy, and mood in behavioural studies. No interaction with the HPA (cortisol) axis, making it a clean tool for studying monoamine modulation independently of stress hormones.
Brain Protection
Significant neuroprotective effects in MCAO rodent models — reduced infarct volume and neuronal death when given before or shortly after ischemic insult. These preclinical data underpin its clinical use in Russia for ischemic stroke recovery. Useful as a positive control in neuroprotection experiments.
Cognitive Performance
Consistent improvements in spatial memory, novel object recognition, and attention tasks in rodent studies. Effects correlate with BDNF upregulation and are reversible — making Semax suitable for acute cognitive enhancement protocols without lasting pharmacological residue.
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