006 — SL-2026-006

IGF-1 LR3

Insulin-like Growth Factor 1 Long R3

IGF-1 LR3 is the long-acting version of IGF-1 — the body's most powerful anabolic signal. The LR3 modification extends its active half-life from 15 minutes to 20–30 hours, making it dramatically more effective for muscle growth, recovery, and cellular repair research.

✓ In Stock Lyophilized Powder 1 mg / vial COA Included
€27.90
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SKUSL-IGF1LR3-1
FormLyophilized Powder
Quantity1 mg / vial
Purity≥98% HPLC
CAS Number946870-92-4
Molecular FormulaC990H1528N262O300S7
Molecular Weight~9117 Da
Storage−20°C, protect from light
Shelf Life24 months (unopened)
Reconstitution0.1% acetic acid, then dilute in PBS; 0.1 mg/mL typical
Overview

What is IGF-1 LR3?

IGF-1 (Insulin-like Growth Factor 1) is the body's primary anabolic hormone — responsible for muscle growth, cellular repair, and tissue maintenance. It's produced in the liver in response to growth hormone and acts on virtually every cell in the body. The problem with native IGF-1 is that it's rapidly neutralised by binding proteins in the bloodstream, giving it a half-life of just 15 minutes.

IGF-1 LR3 solves this. The LR3 modification — a small structural change that reduces binding protein affinity — extends active half-life to 20–30 hours. This means sustained IGF-1 receptor activation that is simply impossible to achieve with the natural molecule. The result is a dramatically more useful research tool for studying everything IGF-1 controls: muscle hypertrophy, cellular survival, glucose metabolism, and tissue regeneration.

It's widely used in performance research, muscle biology, anti-aging studies, and cancer cell biology. Sharp Labs IGF-1 LR3 is supplied as lyophilized powder at ≥98% HPLC purity, with a Certificate of Analysis included with every order.

Key Benefits

What it's
known for.

Muscle Growth & Recovery
Activates the full anabolic cascade via PI3K/Akt/mTOR and MAPK pathways — driving protein synthesis, muscle fiber repair, and hypertrophy. Extended half-life enables sustained receptor activation not achievable with native IGF-1. The preferred tool for skeletal muscle biology and satellite cell research.
Physical Performance
mTOR activation downstream of IGF-1R is central to strength, endurance adaptation, and training response. IGF-1 LR3 also promotes myoblast differentiation via MyoD and myogenin upregulation — making it a key compound for research into the cellular basis of athletic performance and adaptation.
Anti-Aging & Longevity
IGF-1 signalling declines with age — contributing to muscle loss, slower healing, and cellular deterioration. Research into sustained IGF-1R activation with LR3 explores tissue maintenance, cellular survival pathways, and the role of IGF-1 decline in the aging phenotype.
Metabolic Optimization
IGF-1R shares structural homology with the insulin receptor — activating GLUT4 translocation and glucose uptake in muscle and adipose tissue. Enables sustained interrogation of the IGF-1/insulin pathway crosstalk relevant to insulin sensitivity, body composition, and metabolic health research.
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